Diagnostic value of mucin-like associated antigen (MCA) in neoplasms of the mammary gland

• Published in: Ginekologia polska Vol. 64; no. 2; p. 87
• Main Authors: Kopczyński, Z, Stachowicz, A, Kociałkowski, K, Grodecka-Gazdecka, S
• Format: Journal Article
• Language: Polish
• Published: Poland 01.02.1993
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm - blood; Antigens, Tumor-Associated, Carbohydrate; Biomarkers, Tumor - blood; Breast Neoplasms - blood; Breast Neoplasms - diagnosis; Female; Humans; Middle Aged
• ISSN: 0017-0011

The aim of the present study was to evaluate the diagnostic value of the new tumour marker MCA in serum from women with breast cancer. Relationship between presence MCA in serum and cER, cPgR, nER, nPgR in aqueous extracts from cancer tissues was subject of our investigation, too. Immunoenzymatic method (Roche) which employed monoclonal antibody MAb b-12 was used for determination of MCA in serum 49 operable patients (preoperative determination). In a group of 26 cancer patients MCA and cER, cPgR, nER, nPgR were tested simultaneously. Steroid hormone receptors were measured by immunoenzymatic method (Abbott). Mean concentration of MCA in women with breast cancer (n = 36) was higher as compared with control (n = 21, p < 0.001). When 6.86 U/ml was took as mean level of MCA in control group it was found that 46% women with benign tumours, 64% with carcinoma ductal and 62% with carcinoma lobular have had concentrations of MCA below this value. Also it was found that differences between mean levels of MCA and cER, cPgR, nER, nPgR were statistical significance only in women with carcinoma ductal. On the basis of our own investigations we can suggest that MCA has limited value in the diagnosis of breast cancer.