Characteristics of ECHO-19 virus strain Rad/40 causing an experimental lesion of the vascular coat of the eye (uveitis) in cynomolgus monkeys

Four strains of ECHO-19 virus were isolated from a child with respiratory disease complicated with uveitis. A freshly isolated Rad/40 strain of ECHO-19 virus was found to produce a severe disease of the vascular coat of the eye (uveitis) in Javan Cercopithecus monkeys inoculated directly into the an...

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Published inVoprosy virusologiĭ Vol. 27; no. 6; p. 721
Main Authors Koroleva, G A, Savinov, A P, Krichevskaia, G I, Vinogradova, V L, Kataragina, L A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1982
Subjects
Animals
Animals, Newborn
Arvicolinae
Cytopathogenic Effect, Viral
Enterovirus B, Human - pathogenicity
Macaca fascicularis
Mice
Rats
Uveitis - microbiology
Uveitis - pathology
Virus Cultivation
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Summary:Four strains of ECHO-19 virus were isolated from a child with respiratory disease complicated with uveitis. A freshly isolated Rad/40 strain of ECHO-19 virus was found to produce a severe disease of the vascular coat of the eye (uveitis) in Javan Cercopithecus monkeys inoculated directly into the anterior chamber of the eye. Experimental uveitis is characterized by marked changes in the shape of the pupil, the lack of the pupil reaction to light, development of synechias, changes in the color of the iris. No uveitis developed after inoculation of the monkeys with the prototype Burke strain of ECHO-19 virus of culture fluid from uninoculated RD cell cultures (control). It is suggested that the freshly isolated strains of ECHO-19 virus (Rad/40 strain) could cause uveitis in the child under observation.
ISSN:0507-4088