Clinical and biochemical parameters of parkinsonism induced by 1-methyl-4-phenyl-1,2,2,6-tetrahydropyridine and its methyl-phenyl and methoxy-phenyl derivatives in C57Bl/6 mice

Possibility of ortho-, para-, meta-methylphenyl and methoxyphenyl-derivates of MPTP to produce parkinsonism was investigated. Only ortho-methylphenyl- and ortho-methoxyphenyl-derivates of MPTP cause a persistent loss in dopamine content in the brain and produced the clinical symptoms of parkinsonism...

Full description

Saved in:
Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 110; no. 10; p. 397
Main Authors Lermontova, N N, Soliakov, L S, Bachurin, S O, Serkova, T P, Petrova, L N, Dranyĭ, O A, Tkachenko, S E, Kalashnikov, V V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1990
Subjects
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - analogs & derivatives
1-Methyl-4-phenylpyridinium - administration & dosage
1-Methyl-4-phenylpyridinium - adverse effects
Animals
Brain - drug effects
Female
Injections, Intraperitoneal
Mice
Mice, Inbred C57BL
Parkinson Disease, Secondary - chemically induced
Time Factors
Online AccessGet more information

Cover

More Information
Summary:Possibility of ortho-, para-, meta-methylphenyl and methoxyphenyl-derivates of MPTP to produce parkinsonism was investigated. Only ortho-methylphenyl- and ortho-methoxyphenyl-derivates of MPTP cause a persistent loss in dopamine content in the brain and produced the clinical symptoms of parkinsonism. All substances produced Parkinsonian-like syndrome gives the symptoms of activation of nervous system during 0.5-1 h after injection and symptoms of depression in following 3 h of observations.
ISSN:0365-9615