The effect of pharmacologic therapy of hyperthyroidism on automatic heart conduction

Investigations of the heart automatism were carried out in 10 patients with hyperthyreoidism before thiamazol therapy and after restoration of the euthyroid status. A control group was comprised of 34 healthy subjects. In order to determine the electrophysiologic parameters the transoesophageal atri...

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Bibliographic Details
Published inZeitschrift für die gesamte innere Medizin und ihre Grenzgebiete Vol. 44; no. 17; p. 524
Main Authors Jonderko, G, Marcisz, C, Kocot, E
Format Journal Article
LanguageGerman
Published Germany 01.09.1989
Subjects
Adult
Arrhythmias, Cardiac - drug therapy
Cardiac Pacing, Artificial
Dose-Response Relationship, Drug
Electrocardiography
Female
Heart Conduction System - drug effects
Heart Rate - drug effects
Humans
Hyperthyroidism - drug therapy
Male
Methimazole - administration & dosage
Thyroid Function Tests
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Summary:Investigations of the heart automatism were carried out in 10 patients with hyperthyreoidism before thiamazol therapy and after restoration of the euthyroid status. A control group was comprised of 34 healthy subjects. In order to determine the electrophysiologic parameters the transoesophageal atrium extrastimulus technique and the over-driving stimulation were applied. Restoration of the euthyroid status was accompanied by a significant prolongation of the atrial refraction, the border interval, the border conductivity and the sinus rhythm recurrence time. In a half of the patients were atrioventricular and intraventricular conductibility disturbances observed. The authors conclude, that in the early period of the euthyroid status restoration after thiamazole therapy there still exists a risk of cardiologic complications.
ISSN:0044-2542