Characteristics of the psychotropic effects of N-crown ether derivatives

Acyl derivatives of crown esters containing amino acid derivatives as substitutes were studied. Derivatives of N-acylazacrown esters were found in experiments to display a broad spectrum of anticonvulsant activity, antiaggressive and tranquillizing effects and not to produce any sedative and myorela...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 49; no. 4; p. 13
Main Authors Timofeeva, S E, Voronina, T A, Karaseva, T L, Golovenko, N Ia, Garibova, T L
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1986
Subjects
Aggression - drug effects
Animals
Anticonvulsants - therapeutic use
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Ethers, Cyclic - pharmacology
Exploratory Behavior - drug effects
Male
Mice
Psychotropic Drugs - pharmacology
Rats
Seizures - chemically induced
Seizures - drug therapy
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Summary:Acyl derivatives of crown esters containing amino acid derivatives as substitutes were studied. Derivatives of N-acylazacrown esters were found in experiments to display a broad spectrum of anticonvulsant activity, antiaggressive and tranquillizing effects and not to produce any sedative and myorelaxant actions. The profile of psychotropic activity of N-crown esters derivatives seems to be similar to that of atypic tranquillizers but the latters are less toxic.
ISSN:0014-8318