Pathomorphologic changes in experimental siderosis

Experimental hypersiderosis was induced in rabbits by intravenous injection of iron-containing preparation Ferrum Leck. The resultant pronounced hemosiderosis was found in the liver, kidneys, heart, lungs and spleen. Dystrophic and necrotic processes arose in the liver, kidneys, heart. Accumulation...

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Bibliographic Details
Published inArkhiv patologii Vol. 55; no. 1; p. 52
Main Authors Nazaretian, M K, Aĭbazian, L K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1993
Subjects
Animals
Capillary Permeability - physiology
Cell Division - physiology
Coronary Vessels - pathology
Endothelium, Vascular - metabolism
Hemosiderin - metabolism
Kidney - pathology
Liver - pathology
Lung - pathology
Male
Myocardium - pathology
Necrosis
Rabbits
Siderosis - pathology
Spleen - pathology
Viscera - metabolism
Viscera - pathology
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Summary:Experimental hypersiderosis was induced in rabbits by intravenous injection of iron-containing preparation Ferrum Leck. The resultant pronounced hemosiderosis was found in the liver, kidneys, heart, lungs and spleen. Dystrophic and necrotic processes arose in the liver, kidneys, heart. Accumulation of hemosiderin in the vascular walls led to their higher permeability, edema, wall thickness, proliferative changes, especially in the coronary vessels. Intravascular circulation impairment was evident from compression of microvessels by siderophages, red cells aggregation, formation of microthrombi.
ISSN:0004-1955