Gentamycin kinetics when administered into the eyes via soft contact lenses

Pharmacokinetics of gentamicin administered into the eye by means of instillation or hydrophilic contact lenses was studied comparatively. The results of the study showed that gentamicin levels in the humor of the eye anterior chamber after the antibiotic administration with soft contact lenses were...

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Bibliographic Details
Published inAntibiotiki Vol. 25; no. 7; p. 511
Main Authors Zelenskaia, M V, Babich, G A, Shapiro, E I, Kivaev, A A, Bodunkova, L E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1980
Subjects
Animals
Contact Lenses, Hydrophilic
Eye - drug effects
Gentamicins - administration & dosage
Gentamicins - metabolism
In Vitro Techniques
Kinetics
Ophthalmic Solutions
Rabbits
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Summary:Pharmacokinetics of gentamicin administered into the eye by means of instillation or hydrophilic contact lenses was studied comparatively. The results of the study showed that gentamicin levels in the humor of the eye anterior chamber after the antibiotic administration with soft contact lenses were higher at all periods than those after instillation. Higher retention time of gentamicin therapeutic doses in the humor of the eye anterior chamber after the antibiotic administration by means of soft contact lenses is also an advantage of this administration route.
ISSN:0003-5637