Immunomorphological study of the structural proteins of the aortic wall in experimental atherosclerosis in rabbits

Destruction of elastic and collagenous fibers in lipid spots and atherosclerotic plaques in rabbit experimental atherosclerosis is associated with exposure of previously latent antigenous determinants of structural arterial proteins and appearance of circulating antibodies to collagen, elastin and s...

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Bibliographic Details
Published inArkhiv patologii Vol. 42; no. 6; p. 33
Main Authors Ivanovskiĭ, Iu V, Nagornev, V A, Zubzhitskiĭ, Iu N
Format Journal Article
LanguageRussian
Published Russia (Federation) 1980
Subjects
Animals
Aorta - immunology
Aorta - pathology
Arteriosclerosis - immunology
Arteriosclerosis - pathology
Collagen - immunology
Diet, Atherogenic
Elastin - immunology
Glycoproteins - immunology
Proteins - immunology
Rabbits
Time Factors
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Summary:Destruction of elastic and collagenous fibers in lipid spots and atherosclerotic plaques in rabbit experimental atherosclerosis is associated with exposure of previously latent antigenous determinants of structural arterial proteins and appearance of circulating antibodies to collagen, elastin and structural glycoproteins. By the 4th month of the experiment there is an abrupt decrease in the titres of the above antibodies fixed to degeneratively altered fibrous structures of the aortal wall. Sedimentation of circulatory antivascular antibodies is associated with the enhanced destruction of collagenous and elastic fibers, with proliferation of the connective tissue and dramatic progress of the atherosclerotic process.
ISSN:0004-1955