The quality of the preservation of lungs using different solutions (an experimental study)

Effects of different perfusion conditions and storage of isolated dog lungs on the process of edema development were studied. Sixty-nine mongrel dogs were used in the study. In case of a 15 min perfusion via the pulmonary artery and 12 h storage lung condition depended mainly on the type of solution...

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Published inGrudnaia i serdechno-sosudistaia khirurgiia no. 6; p. 65
Main Authors Khodzhimatov, G M, Movsesov, R V, Zhavoronkov, N A, Ivanova, A G, Zhidkov, I L, Sheremet'eva, G F, Dement'eva, I I, Perel'man, M I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1993
Subjects
Animals
Antioxidants
Dextrans
Dogs
Evaluation Studies as Topic
Female
Glucose
Hypertonic Solutions
Lung - pathology
Lung - physiology
Male
Organ Preservation - methods
Perfusion - instrumentation
Perfusion - methods
Pulmonary Edema - etiology
Pulmonary Edema - pathology
Reperfusion Injury - etiology
Reperfusion Injury - pathology
Time Factors
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Summary:Effects of different perfusion conditions and storage of isolated dog lungs on the process of edema development were studied. Sixty-nine mongrel dogs were used in the study. In case of a 15 min perfusion via the pulmonary artery and 12 h storage lung condition depended mainly on the type of solution and addition of protective drugs to this solution. Euro-Collins and low-potassium electrolytic solution markedly increased capillary hydrostatic pressure and drastically reduced plasma colloid-osmotic pressure. As a result filtration coefficient increased and as soon as an hour after reperfusion onset a marked pulmonary edema developed. Use of LPD solution without drugs added for 2.5 h reperfusion was associated with a moderate increase of capillary hydrostatic pressure and negligible decrease of plasma colloid-osmotic pressure. If the reperfusion were longer plasma colloid-osmotic pressure reduced, this leading to development of moderate pulmonary edema. A 15 min lung perfusion via the pulmonary artery and 12 h storage at 1 degree C in LPD solution with membrane protectors and antioxidants was associated with virtually unchanged capillary hydrostatic pressure, plasma colloid-osmotic pressure, and filtration coefficient and, hence, no pulmonary edema.
ISSN:0236-2791