Kinetics of 7-aminocephalosporanic acid in aqueous solutions

Stability of 7-aminocephalosporanic acid (7-ACA) and desacetyl-7-ACA in aqueous solutions at the pH value higher than 6 and wide ranges of the temperature was studied. The kinetic parameters of the hydrolysis of the ester link in the molecule of 7-ACA and the openings of the betalactam link in the m...

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Bibliographic Details
Published inAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 40; no. 3; p. 3
Main Authors Kurochkina, V B, Larina, E V, Nys, P S, Libinson, G S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1995
Subjects
Biotransformation
Catalysis
Cephalosporins - pharmacokinetics
Drug Stability
Hydrogen-Ion Concentration
Solutions
Temperature
Water - chemistry
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Summary:Stability of 7-aminocephalosporanic acid (7-ACA) and desacetyl-7-ACA in aqueous solutions at the pH value higher than 6 and wide ranges of the temperature was studied. The kinetic parameters of the hydrolysis of the ester link in the molecule of 7-ACA and the openings of the betalactam link in the molecules of 7-ACA and desacetyl-7-ACA were estimated. It was shown that all the destruction processes were describable by the 1st order equations. A procedure for the calculation of the velocity constants of the above mentioned three processes by changes in the concentration of 7-ACA and desacetyl-7-ACA in the solutions is described.
ISSN:0235-2990