Effect of tuftsin on the orientation-exploratory behavior of normal white rats and against a background of pharmacologically induced disorders of the brain biogenic amine system

The application of "hole board" method showed that the endogenic immunostimulator tetrapeptide tuftsin injected intraperitoneally in dose 0.3 mg/kg has a short-time stimulating action on the orienting reaction of rats in 5 min, though in 24 hours it suppresses the registered behavioral ind...

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Bibliographic Details
Published inNauchnye doklady vysshei shkoly. Biologicheskie nauki no. 3; p. 70
Main Authors Sarycheva, N Iu, Kalikhevich, V N, Kamenskiĭ, A A, Vlasov, T I
Format Journal Article
LanguageRussian
Published Russia (Federation) 1989
Subjects
Animals
Biogenic Amines - analysis
Biogenic Amines - physiology
Brain - drug effects
Brain - physiology
Brain Chemistry - drug effects
Exploratory Behavior - drug effects
Male
Orientation - drug effects
Rats
Time Factors
Tuftsin - pharmacology
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Summary:The application of "hole board" method showed that the endogenic immunostimulator tetrapeptide tuftsin injected intraperitoneally in dose 0.3 mg/kg has a short-time stimulating action on the orienting reaction of rats in 5 min, though in 24 hours it suppresses the registered behavioral indexes. The pharmacological analysis of the above studied phenomenon showed that catecholaminergic and especially dopaminergic brain systems played the leading role in tuftsin effect. Tuftsin can normalize animals' behaviour disturbed by the pharmacological agents, which slightly influence the functioning of the brain dopaminergic system.
ISSN:0470-4606