Potentiation by blastolysin of the effect of cyclophosphamide in preventing recurrence in mouse T-cell leukemia

Injection of cyclophosphamide in a dose of 100 mg/kg two or four times at 18- or 7-day intervals, respectively, prolonged the remission in EL-4-leukemia-bearing C57Bl/6j mice induced by cytosar under deoxycytidine protection. Injection of blastolysin in a dose of 25 mg/kg once a week at the same per...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 98; no. 7; p. 57
Main Authors Chertkova, A I, Bukhman, V M, Syrkin, A B
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1984
Subjects
Animals
Anti-Bacterial Agents
Antibiotics, Antineoplastic - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cyclophosphamide - therapeutic use
Drug Synergism
Glycopeptides - therapeutic use
Male
Mice
Mice, Inbred C57BL
Neoplasm Recurrence, Local - prevention & control
Neoplasm Transplantation
Thymoma - drug therapy
Thymus Neoplasms - drug therapy
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Summary:Injection of cyclophosphamide in a dose of 100 mg/kg two or four times at 18- or 7-day intervals, respectively, prolonged the remission in EL-4-leukemia-bearing C57Bl/6j mice induced by cytosar under deoxycytidine protection. Injection of blastolysin in a dose of 25 mg/kg once a week at the same period had no effect. However, blastolysin potentiated the antirelapse effect of cyclophosphamide. It is suggested that the potentiation of the cyclophosphamide effect with blastolysin is mediated by activation of antitumor immunological reactivity.
ISSN:0365-9615