Study of pantothenic acid derivatives as cardiac protectors in a model of experimental ischemia and reperfusion of the isolated heart

An isolated heart model with experimental ischemia and reperfusion was used to show effective decrease in lactate, increase in ATP content and prevention of conjugated dienes accumulation in the myocardium by derivatives of pantothenic acid: panthenol (9.0 mg/kg), calcium pantothenate (15.6 mg/kg) a...

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Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 113; no. 4; p. 373
Main Authors Kumerova, A O, Utno, L Ia, Lipsberga, Z E, Shkestere, I Ia
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.1992
Subjects
Adenosine Triphosphate - metabolism
Animals
Heart - drug effects
In Vitro Techniques
Lactates - metabolism
Lipid Peroxidation
Male
Myocardium - metabolism
Pantetheine - analogs & derivatives
Pantetheine - pharmacology
Pantothenic Acid - analogs & derivatives
Pantothenic Acid - pharmacology
Phosphocreatine - metabolism
Rats
Rats, Wistar
Reperfusion Injury
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Summary:An isolated heart model with experimental ischemia and reperfusion was used to show effective decrease in lactate, increase in ATP content and prevention of conjugated dienes accumulation in the myocardium by derivatives of pantothenic acid: panthenol (9.0 mg/kg), calcium pantothenate (15.6 mg/kg) and by these ones applied simultaneously as ingredients of perfusate (25 microM) in postischemic period. In that way derivatives of pantothenic acid should be regarded as cardiac protectors.
ISSN:0365-9615