The phospholipid composition of the liver and the glycolipid spectrum of the brain in rats administered cyanamide

The effect of cyanamide on the liver phospholipids and brain glycolipids was studied (on rats). It was found that cyanamide (60 mg/kg, intraperitoneally) increased the amount of liver lysophosphatidylcholine, sphingomyelin, cardiolipin and decreased phosphatidylcholine and phosphatidylethanolamine....

Full description

Saved in:
Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 59; no. 6; p. 38
Main Authors Selevich, M I, Lepevich, V V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1996
Subjects
Animals
Brain - drug effects
Brain Chemistry - drug effects
Cyanamide - pharmacology
Drug Interactions
Ethanol - pharmacology
Glycolipids - analysis
Liver - chemistry
Liver - drug effects
Male
Phospholipids - analysis
Rats
Online AccessGet more information

Cover

More Information
Summary:The effect of cyanamide on the liver phospholipids and brain glycolipids was studied (on rats). It was found that cyanamide (60 mg/kg, intraperitoneally) increased the amount of liver lysophosphatidylcholine, sphingomyelin, cardiolipin and decreased phosphatidylcholine and phosphatidylethanolamine. Similar but more pronounced alterations of liver phospholipids were found after ethanol administration 91 g/kg, 20% solution intraperitoneally) under the influence of cyanamide. After cyanamide and its combination with alcohol brain concentrations of sulfatides I, II as well as cerebrosides l, II and III decreased.
ISSN:0869-2092