Dynamics of isolation of mycobacterium tuberculosis during 2-stage standard chemotherapy

Two-stage standard chemotherapy was performed in 149 newly detected patients with pulmonary tuberculosis, by isolating Mycobacteria. Within the first 2 months, the patients received 4 drugs: isoniazid, rifampicin, pyrazinamide, streptomycin or ethambutol. Treatment with two agents (isoniazid and rif...

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Bibliographic Details
Published inProblemy tuberkuleza no. 6; p. 52
Main Authors Khomenko, A G, Vasil'eva, I A
Format Journal Article
LanguageRussian
Published Russia (Federation) 1996
Subjects
Adolescent
Adult
Aged
Antitubercular Agents - therapeutic use
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Lung - microbiology
Male
Middle Aged
Mycobacterium tuberculosis - isolation & purification
Treatment Outcome
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - microbiology
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Summary:Two-stage standard chemotherapy was performed in 149 newly detected patients with pulmonary tuberculosis, by isolating Mycobacteria. Within the first 2 months, the patients received 4 drugs: isoniazid, rifampicin, pyrazinamide, streptomycin or ethambutol. Treatment with two agents (isoniazid and rifampicin) was continued for 4 months. Mycobacterial isolation was stopped in 104 patients after 2 months of treatment, in other 26 after 3 months, which amounts to 80.2%. Higher therapeutical results were observed in patients who had isolated Mycobacteria resistant to 1 and even 2 drugs.
ISSN:0032-9533