Development of the connective tissue in the wall of the rabbit aorta in experimental atherosclerosis

Structural and functional characteristics of cells involved in collagen synthesis have been studied in experimental hypercholesterolemia in rabbits. Autoradiographic studies, using 3H-proline and 14C-hydroxyproline have demonstrated that collagen synthesis takes place only in the intima in the area...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 105; no. 1; p. 90
Main Authors NagornevBA, Babushkina, T G, Bobryshev, Iu V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1988
Subjects
Animals
Aorta - pathology
Arteriosclerosis - pathology
Connective Tissue - pathology
Diet, Atherogenic
Hypercholesterolemia - pathology
Rabbits
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Summary:Structural and functional characteristics of cells involved in collagen synthesis have been studied in experimental hypercholesterolemia in rabbits. Autoradiographic studies, using 3H-proline and 14C-hydroxyproline have demonstrated that collagen synthesis takes place only in the intima in the area of cellular proliferation. At earlier stages of experimental atherosclerosis collagen synthesis predominantly involves synthetic GABA phenotype, while at progressing stages fibroblasts are predominantly involved.
ISSN:0365-9615