The technology for manufacturing antiparasitic preparations. 4. The development of a technology for producing the anthelmintic bromoksan in finely dispersed form and the evaluation of its antifascioliasis activity

A manufacturing procedure has been developed to prepare the anthelmintic bromoxane as a finely divided dosage form. The maximum toxic dose of the drug was 1 g per kg mice body weight. Its therapeutic dose in sheep fascioliasis was 20 mg/kg.

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Bibliographic Details
Published inMeditsinskaia parazitologiia i parazitarnye bolezni no. 3; p. 41
Main Authors Mikhaĭlitsyn, F S, Petrov, Iu F, Bol'shakova, A Iu, Lebedeva, M N, Lychko, N D
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1995
Subjects
Animals
Antiplatyhelmintic Agents - chemical synthesis
Antiplatyhelmintic Agents - therapeutic use
Antiplatyhelmintic Agents - toxicity
Benzamides - chemical synthesis
Benzamides - therapeutic use
Benzamides - toxicity
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical - veterinary
Fascioliasis - drug therapy
Fascioliasis - veterinary
Mice
Sheep
Sheep Diseases - drug therapy
Technology, Pharmaceutical
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Summary:A manufacturing procedure has been developed to prepare the anthelmintic bromoxane as a finely divided dosage form. The maximum toxic dose of the drug was 1 g per kg mice body weight. Its therapeutic dose in sheep fascioliasis was 20 mg/kg.
ISSN:0025-8326