Antimutagenic properties of Angelica archangelica L

The antimutagenic activity of Angelica archangelica L. aqueous and alcohol extracts of thio-TEPA against mutagenicity was examined by the micronucleus test in murine bone marrow cells. The reduction of Thio-TEPA's mutagenic activity was more profound when the extracts were injected 2 hours befo...

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Bibliographic Details
Published inVestnik Rossiĭskoĭ akademii medits︠i︡nskih nauk no. 1; p. 58
Main Authors Salikhova, R A, Poroshenko, G G
Format Journal Article
LanguageRussian
Published Russia (Federation) 1995
Subjects
Animals
Antimutagenic Agents
Bone Marrow - drug effects
Bone Marrow Cells
Chromosome Aberrations
Mice
Micronucleus Tests
Mutagenesis - drug effects
Plants, Medicinal
Thiotepa - toxicity
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Summary:The antimutagenic activity of Angelica archangelica L. aqueous and alcohol extracts of thio-TEPA against mutagenicity was examined by the micronucleus test in murine bone marrow cells. The reduction of Thio-TEPA's mutagenic activity was more profound when the extracts were injected 2 hours before thio-TEPA treatment, as seen during simultaneous treatment. The observed reduction of micronuclear frequencies was as high as 77%.
ISSN:0869-6047