Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II
Hepatocytes obtained from rats partially hepatectomized 72 h before experimentation are insensitive to alpha 1-adrenergic amines, vasopressin, angiotensin II and ionophore A23187. However, if inositol is administered to the rats 24 and 48 h after surgery, the above-mentioned hormones stimulate glyco...
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Published in | Biochimica et biophysica acta Vol. 763; no. 2; pp. 125 - 128 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Netherlands
22.09.1983
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Subjects | |
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Abstract | Hepatocytes obtained from rats partially hepatectomized 72 h before experimentation are insensitive to alpha 1-adrenergic amines, vasopressin, angiotensin II and ionophore A23187. However, if inositol is administered to the rats 24 and 48 h after surgery, the above-mentioned hormones stimulate glycogenolysis, gluconeogenesis and ureogenesis in the newly formed hepatocytes. Furthermore, ionophore A23187 is able to stimulate glycogenolysis in these cells, the mechanism through which inositol produces this effect being unknown. A rôle for phosphatidylinositol is suggested. |
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AbstractList | Hepatocytes obtained from rats partially hepatectomized 72 h before experimentation are insensitive to alpha 1-adrenergic amines, vasopressin, angiotensin II and ionophore A23187. However, if inositol is administered to the rats 24 and 48 h after surgery, the above-mentioned hormones stimulate glycogenolysis, gluconeogenesis and ureogenesis in the newly formed hepatocytes. Furthermore, ionophore A23187 is able to stimulate glycogenolysis in these cells, the mechanism through which inositol produces this effect being unknown. A rôle for phosphatidylinositol is suggested. |
Author | Huerta-Bahena, J García-Saínz, J A |
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SubjectTerms | Angiotensin II - pharmacology Animals Arginine Vasopressin - pharmacology Calcimycin - pharmacology Female Gluconeogenesis - drug effects Inositol - pharmacology Liver - drug effects Liver Glycogen - metabolism Liver Regeneration Rats Rats, Inbred Strains Sympathomimetics - pharmacology Urea - metabolism |
Title | Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II |
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