Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II

Hepatocytes obtained from rats partially hepatectomized 72 h before experimentation are insensitive to alpha 1-adrenergic amines, vasopressin, angiotensin II and ionophore A23187. However, if inositol is administered to the rats 24 and 48 h after surgery, the above-mentioned hormones stimulate glyco...

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Published inBiochimica et biophysica acta Vol. 763; no. 2; pp. 125 - 128
Main Authors Huerta-Bahena, J, García-Saínz, J A
Format Journal Article
LanguageEnglish
Published Netherlands 22.09.1983
Subjects
Angiotensin II - pharmacology
Animals
Arginine Vasopressin - pharmacology
Calcimycin - pharmacology
Female
Gluconeogenesis - drug effects
Inositol - pharmacology
Liver - drug effects
Liver Glycogen - metabolism
Liver Regeneration
Rats
Rats, Inbred Strains
Sympathomimetics - pharmacology
Urea - metabolism
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Summary:Hepatocytes obtained from rats partially hepatectomized 72 h before experimentation are insensitive to alpha 1-adrenergic amines, vasopressin, angiotensin II and ionophore A23187. However, if inositol is administered to the rats 24 and 48 h after surgery, the above-mentioned hormones stimulate glycogenolysis, gluconeogenesis and ureogenesis in the newly formed hepatocytes. Furthermore, ionophore A23187 is able to stimulate glycogenolysis in these cells, the mechanism through which inositol produces this effect being unknown. A rôle for phosphatidylinositol is suggested.
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ISSN:0006-3002