Characteristics of the clinical aspects, and hormonal and immunological status of thyrotoxicosis patients with a hereditary predisposition to endocrine diseases

The levels of triiodothyronine (T3), thyroxine (T4), TTH, STH, free triiodothyronine index T3F/T3/T4, as well as the titers of antibodies to microsome-membranous antigen and thyroglobulin, were studied in thyrotoxic patients with hereditary predisposition to endocrine diseases (thyrotoxicosis, goite...

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Published inProblemy ėndokrinologii Vol. 28; no. 4; p. 9
Main Authors Natarov, V V, Grinchenko, T S, Afanas'eva, N I, Ivanov, E N, Dekhtiar', D A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1982
Subjects
Adolescent
Adult
Antibody Formation
Diabetes Mellitus - genetics
Diabetes Mellitus - physiopathology
Disease Susceptibility
Female
Goiter - genetics
Goiter - physiopathology
Humans
Hyperthyroidism - genetics
Hyperthyroidism - physiopathology
Male
Middle Aged
Thyroid Gland - immunology
Thyroid Hormones - blood
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Summary:The levels of triiodothyronine (T3), thyroxine (T4), TTH, STH, free triiodothyronine index T3F/T3/T4, as well as the titers of antibodies to microsome-membranous antigen and thyroglobulin, were studied in thyrotoxic patients with hereditary predisposition to endocrine diseases (thyrotoxicosis, goiter, diabetes mellitus) and in subjects without such heredity. Peculiarities of the disease development and endocrinopathy distribution among their relatives were investigated. More pronounced disorders in thyroid hormone metabolism and humoral immunity state were seen in thyrotoxic patients with hereditary predisposition to endocrine diseases. In comparison with those of the subjects without this heredity. The risk of diabetes mellitus development was detected in thyrotoxic patients predisposed to diabetes mellitus. Clinical manifestations of thyrotoxicosis (the disease severity, goiter of the IVth sage, exophthalmos) were also more evident in subjects predisposed to endocrine diseases.
ISSN:0375-9660