Liver ultrastructural changes following portal circulation disturbances

Liver cell changes produced in rats by the ligature of the portal vein and of the spleen pedicle were studied by electron microscopy. There were differences in the liver response to the various types of circulatory disturbances. The earliest and most marked lesions of hepatic cells were noticed in t...

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Bibliographic Details
Published inMorphologie et embryologie Vol. 27; no. 1; p. 73
Main Authors Cotuţiu, C, Dobrescu, G, Bârsu, M, Stoica, L
Format Journal Article
LanguageEnglish
Published Romania 01.01.1981
Subjects
Animals
Liver - ultrastructure
Liver Circulation
Liver Diseases - pathology
Portal System
Rats
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Summary:Liver cell changes produced in rats by the ligature of the portal vein and of the spleen pedicle were studied by electron microscopy. There were differences in the liver response to the various types of circulatory disturbances. The earliest and most marked lesions of hepatic cells were noticed in the case of portal vein ligature, and occurred at the level of rough endoplasmic reticulum, mitochondria and lysosomes. No significant changes in Kupffer cells. When the spleen pedicle was ligated, the hepatic cell changes were less obvious, but the Kupffer cells changes were more prominent, testifying and increased hetero- and autophagy.
ISSN:0377-5038