Experimental model for studying the participation of bone marrow cells in antibody formation

Participation of bone marrow cells in the production of IgM antibody forming cells (AFC) in the primary immune response to sheep red blood cells (SRBC) in C57Bl/6 and BDA/2 mice was studied. The animals of this line differed in sensitivity to preoral benz(a)pyren (BP) injection. After BP injection a...

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Published inT͡S︡itologii͡a Vol. 28; no. 1; p. 102
Main Authors Tsyrlova, I G, Kozlov, V A, Tsyrlov, I B
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1986
Subjects
Animals
Antibody Formation - drug effects
Antibody-Producing Cells - drug effects
Antibody-Producing Cells - immunology
Benzo(a)pyrene - pharmacology
Benzopyrene Hydroxylase - metabolism
Bone Marrow - drug effects
Bone Marrow - immunology
Bone Marrow Cells
Cell Differentiation - drug effects
Cell Division - drug effects
Immunization - methods
Immunoglobulin M - biosynthesis
Intestines - enzymology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Microsomes, Liver - enzymology
Models, Biological
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Summary:Participation of bone marrow cells in the production of IgM antibody forming cells (AFC) in the primary immune response to sheep red blood cells (SRBC) in C57Bl/6 and BDA/2 mice was studied. The animals of this line differed in sensitivity to preoral benz(a)pyren (BP) injection. After BP injection a toxical injury of bone marrow cells was observed for two days in DBA 2 mice but was not marked in C57Bl/6 mice. In the former it was followed by a 10-fold decrease of IgMAFC, while no profound changes were noticed in the immune response of the latter. A new model is offered for the evaluation of bone marrow cell participation. A suggestion is made concerning some connection of immunodepression in the bone marrow with the change of the stem hemopoietic precursor differentiation.
ISSN:0041-3771