The effect of a one-time administration of phenobarbital and carbon tetrachloride on comuton activity in the rat liver

Infusion of phenobarbital and CCl4 was found to induce comuton control of mitochondrial respiration in a liver of starved rats. Comuton regulation of liver mitochondria respiration can be activated either by increase in liver activity or by damage caused by CCl4. The comuton regulation is directly i...

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Bibliographic Details
Published inIzvestiia Akademii nauk SSSR. Seriia biologicheskaia no. 5; p. 666
Main Authors Elbakidze, G M, Chelidze, M A, Elbakidze, I M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1989
Subjects
Animals
Carbon Tetrachloride - pharmacology
Kidney - drug effects
Kidney - metabolism
Male
Microsomes, Liver - drug effects
Microsomes, Liver - metabolism
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Oxidative Phosphorylation - drug effects
Oxygen Consumption - drug effects
Phenobarbital - pharmacology
Rats
Time Factors
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Summary:Infusion of phenobarbital and CCl4 was found to induce comuton control of mitochondrial respiration in a liver of starved rats. Comuton regulation of liver mitochondria respiration can be activated either by increase in liver activity or by damage caused by CCl4. The comuton regulation is directly induced by disturbance of energetic homeostasis of liver cells.
ISSN:0002-3329