The effect of prolonged gamma irradiation at a decreasing dose rate on survivability and gene mutation induction in cultured Chinese hamster cells

Continuous gamma irradiation at decreasing dose rate was shown to be less effective than acute exposure with regard to the lethal effect and frequency of mutations of resistance to 6-thioguanine in cultured Chinese hamster cells. The cell population subjected to continuous irradiation was more radio...

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Bibliographic Details
Published inRadiobiologiia Vol. 31; no. 2; p. 195
Main Authors Feoktistova, T P, Elisova, T V, Stavrakova, N M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1991
Subjects
Animals
Cell Line
Cell Survival - radiation effects
Cells, Cultured - radiation effects
Cricetinae
Cricetulus
Dose-Response Relationship, Radiation
Drug Resistance - radiation effects
Fibroblasts - radiation effects
Gamma Rays
Genes - radiation effects
Mitotic Index - radiation effects
Mutation - radiation effects
Thioguanine - antagonists & inhibitors
Time Factors
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Summary:Continuous gamma irradiation at decreasing dose rate was shown to be less effective than acute exposure with regard to the lethal effect and frequency of mutations of resistance to 6-thioguanine in cultured Chinese hamster cells. The cell population subjected to continuous irradiation was more radioresistant than the intact one. Lethal and genetic effects of continuous irradiation at decreasing dose rate were mainly determined by the contribution of the radiation dose received during the first 24 h of exposure.
ISSN:0033-8192