The effect of reaferon and alpha-tocopherol on lipid peroxidation in experimental influenza

Reaferon administered to outbred young mice with experimental influenza had a positive effect on morphologic changes in pulmonary tissues and on lipid peroxidation in the blood plasma and pulmonary tissues. Combined use of reaferon and alpha-tocopherol in mice infected with influenza A virus reduced...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 40; no. 2; p. 59
Main Authors Pertseva, N G, Ananenko, A A, Malinovskaia, V V, Klembovskiĭ, A I, Burova, V Ia, Meshkova, E N, Kleĭmenova, N V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1995
Subjects
Animals
Antiviral Agents - pharmacology
Influenza A virus - drug effects
Interferon Type I - pharmacology
Interferon-alpha
Lipid Peroxidation - drug effects
Mice
Orthomyxoviridae Infections - metabolism
Orthomyxoviridae Infections - virology
Recombinant Proteins
Vitamin E - pharmacology
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Summary:Reaferon administered to outbred young mice with experimental influenza had a positive effect on morphologic changes in pulmonary tissues and on lipid peroxidation in the blood plasma and pulmonary tissues. Combined use of reaferon and alpha-tocopherol in mice infected with influenza A virus reduced the mortality rate, boosted the antiviral effect of reaferon proper, and led to virtually complete normalization of lipid peroxidation processes in the blood plasma and pulmonary tissues.
ISSN:0507-4088