The role of an endogenous digoxin-like factor in regulating blood circulation and in the origin of arrhythmia in myocardial ischemia

• Published in: Terapevtic̆eskii arhiv Vol. 61; no. 7; p. 84
• Main Authors: Bagrov, A Ia, Zhabko, E P, Maslova, M N, Rukoiatkina, N I, Ukhanova, M V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1989
• Subjects: Acute Disease; Animals; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - physiopathology; Blood Circulation - physiology; Blood Proteins - antagonists & inhibitors; Blood Proteins - physiology; Cardenolides; Coronary Disease - complications; Coronary Disease - physiopathology; Digoxin; Female; Humans; Male; Middle Aged; Ouabain - pharmacology; Rats; Rats, Inbred Strains; Saponins; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors; Sodium-Potassium-Exchanging ATPase - physiology

The history of the discovery of endogenous digoxin-like factor (EDF) is described and the role played by the substance in blood circulation regulation, in the pathogenesis of arterial hypertension is discussed. The authors provide their own data (both experimental and clinical ones) concerned with E...