The role of an endogenous digoxin-like factor in regulating blood circulation and in the origin of arrhythmia in myocardial ischemia

The history of the discovery of endogenous digoxin-like factor (EDF) is described and the role played by the substance in blood circulation regulation, in the pathogenesis of arterial hypertension is discussed. The authors provide their own data (both experimental and clinical ones) concerned with E...

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Published inTerapevtic̆eskii arhiv Vol. 61; no. 7; p. 84
Main Authors Bagrov, A Ia, Zhabko, E P, Maslova, M N, Rukoiatkina, N I, Ukhanova, M V
Format Journal Article
LanguageRussian
Published Russia (Federation) 1989
Subjects
Acute Disease
Animals
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - physiopathology
Blood Circulation - physiology
Blood Proteins - antagonists & inhibitors
Blood Proteins - physiology
Cardenolides
Coronary Disease - complications
Coronary Disease - physiopathology
Digoxin
Female
Humans
Male
Middle Aged
Ouabain - pharmacology
Rats
Rats, Inbred Strains
Saponins
Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
Sodium-Potassium-Exchanging ATPase - physiology
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Summary:The history of the discovery of endogenous digoxin-like factor (EDF) is described and the role played by the substance in blood circulation regulation, in the pathogenesis of arterial hypertension is discussed. The authors provide their own data (both experimental and clinical ones) concerned with EDF participation in the pathogenesis of early ventricular fibrillations in acute myocardial ischemia. Experiments on rats demonstrated that myocardial infarction (MI) is marked by a negative linear correlation between the intensity of ventricular fibrillations and the activity of Na,K-ATPase of intact red blood cells (r = -0.84) that mirrors the content of circulating EDF. Administration to the animals of digoxin antibodies binding EDF resulted in the antiarrhythmic effect and in the recovery of the enzyme activity. The patients demonstrated, within the first day of MI, a 76-percent inhibition of the activity of Na,K-ATPase of red blood cells. A correlation was discovered between the enzyme activity and the capacity of protein-free supernatants of blood plasma for inhibiting Na,K-ATPase, which indicates the presence of circulating EDF in blood plasma.
ISSN:0040-3660