Changes in the kallikrein-kinin system in chronic hemodialysis patients

The pre-kallikrein values, kallikrein inhibitors and protamine-splitting activity were determined in patients treated by means of chronic haemodialysis. Frequent use of dialysers leads to significant changes in the pre-kallikrein and kallikrein-inhibitor values. On the other hand the pre-kallikrein...

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Bibliographic Details
Published inZeitschrift fur Urologie und Nephrologie Vol. 75; no. 2; p. 81
Main Authors Jankova, T, Nenov, D
Format Journal Article
LanguageGerman
Published Germany 01.02.1982
Subjects
Adolescent
Adult
Humans
Kallikreins - antagonists & inhibitors
Kallikreins - blood
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - therapy
Kinins - metabolism
Middle Aged
Prekallikrein - blood
Protamines - blood
Renal Dialysis - adverse effects
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Summary:The pre-kallikrein values, kallikrein inhibitors and protamine-splitting activity were determined in patients treated by means of chronic haemodialysis. Frequent use of dialysers leads to significant changes in the pre-kallikrein and kallikrein-inhibitor values. On the other hand the pre-kallikrein value remains unchanged after a single use of the capillary kidneys Hemoflow (Fresenius). A much smaller decrease in the kallikrein inhibitor value is observed than after frequent use of dialysers. In all the patients investigated the total protamine-splitting activity remained unchanged. Under these circumstances the inhibition capacity is probably sufficient to guarantee a control with respect to fibrinolysis, blood coagulation and the production of kinine.
ISSN:0044-3611