Morphology of the pancreas during intra-aortal administration of 5-fluorouracil

The results of the studies of morphological changes in the pancreas during intraaortal injections of various 5-fluorouracil doses to 44 dogs are reported. It was experimentally established that intraaortal injection of 10 mg 5-fluorouracil per kg of mass for 3 days caused the delay in albumin-synthe...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 101; no. 5; p. 619
Main Authors Titova, G P, Laptev, V V, Gaziev, R M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1986
Subjects
Animals
Aorta
Dogs
Fluorouracil - administration & dosage
Fluorouracil - therapeutic use
Injections, Intra-Arterial
Pancreas - drug effects
Pancreas - pathology
Pancreatitis - drug therapy
Pancreatitis - pathology
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Summary:The results of the studies of morphological changes in the pancreas during intraaortal injections of various 5-fluorouracil doses to 44 dogs are reported. It was experimentally established that intraaortal injection of 10 mg 5-fluorouracil per kg of mass for 3 days caused the delay in albumin-synthesizing organella function, without damaging organellas as such. Administration of a cytostatic in a dose of 15 mg per kg of mass did not only cause a drastic decline in the synthesizing activity of cells in acinar parenchyma, but also induced intracellular lesions.
ISSN:0365-9615