Loss of intravenous nitroglycerin administered with polyvinyl chloride infusion systems

To evaluate the consequences of the interaction between intravenous nitroglycerin (NTG) and infusion systems made of polyvinyl chloride (PVC), 20 dilutions of NTG were prepared in glass bottles with an initial concentration of 200 micrograms/ml, which were infused through 20 infusion systems at a ra...

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Bibliographic Details
Published inMedicina clínica Vol. 96; no. 4; p. 129
Main Authors Barranco Ruiz, F, Sánchez Alarcón, M A, Lesmes Serrano, A, Martínez Ruiz, D, Barranco Sánchez, R
Format Journal Article
LanguageSpanish
Published Spain 02.02.1991
Subjects
Infusion Pumps
Infusions, Intravenous - instrumentation
Nitroglycerin - administration & dosage
Nitroglycerin - chemistry
Polyvinyl Chloride - chemistry
Time Factors
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Summary:To evaluate the consequences of the interaction between intravenous nitroglycerin (NTG) and infusion systems made of polyvinyl chloride (PVC), 20 dilutions of NTG were prepared in glass bottles with an initial concentration of 200 micrograms/ml, which were infused through 20 infusion systems at a rate of 20 ml/hour during 12 hours. NTG concentrations collected at the terminal part of the infusion systems were evaluated after 5 minutes, 6 hours and 12 hours. The results showed a substantial loss of NTG through PVC systems. The loss was 20% after 5 minutes and up to 32% after 12 hours. These results, obtained with a preparation similar to that used in clinical practice, may be helpful to estimate the real dose of the infused drug.
ISSN:0025-7753