Current data on GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) in acute myeloid leukemia

GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) activates neutrophil, eosinophil, granular, and macrophage precursors through binding to specific receptors. GM-CSF receptor is a member of the "cytokine receptor superfamily", which displays a particular transmembrane structure. It...

Full description

Saved in:
Bibliographic Details
Published inBulletin du cancer Vol. 79; no. 2; p. 123
Main Authors de Gentile, A, Schlageter, M H, Krawice, I, Dombret, H, Najean, Y, Chomienne, C, Toubert, M E
Format Journal Article
LanguageFrench
Published France 1992
Subjects
Colony-Stimulating Factors - physiology
Humans
Leukemia, Myeloid, Acute - blood
Receptors, Colony-Stimulating Factor - analysis
Receptors, Colony-Stimulating Factor - physiology
Online AccessGet more information

Cover

More Information
Summary:GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) activates neutrophil, eosinophil, granular, and macrophage precursors through binding to specific receptors. GM-CSF receptor is a member of the "cytokine receptor superfamily", which displays a particular transmembrane structure. It is expressed in small amounts on normal mature blood or medullary cells, with a high affinity. On acute myeloid leukemia blasts (18 patients), our results agree with the review of the literature: GM-CSF receptors are in small amounts, of two types (high and low affinity), with no relation to the FAB classification of leukemias.
ISSN:0007-4551