Effect of peptides of the tracheal mucosa and vascular wall in acute hyperoxic lung injury

It was demonstrated that peptides of the tracheal mucosa (PTM) and peptides of the vascular wall (PVW) produce a certain protective effect in hyperoxic lung injury. The peptides, (PTM to a greater measure) prolonged the survival of mice and inhibited the dynamics of the growth of the lung coefficien...

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Published inPatologicheskaia fiziologiia i eksperimental'naia terapiia no. 3; p. 7
Main Authors Khavinson, V Kh, Kozhemiakin, A L, Kuleshov, V I, Okuneva, N E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1992
Subjects
Animals
Endothelium, Vascular - chemistry
Lung Diseases - chemically induced
Lung Diseases - mortality
Lung Diseases - pathology
Lung Diseases - prevention & control
Male
Mice
Mucous Membrane - chemistry
Oxygen - toxicity
Peptides - pharmacology
Rats
Rats, Wistar
Trachea - blood supply
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Summary:It was demonstrated that peptides of the tracheal mucosa (PTM) and peptides of the vascular wall (PVW) produce a certain protective effect in hyperoxic lung injury. The peptides, (PTM to a greater measure) prolonged the survival of mice and inhibited the dynamics of the growth of the lung coefficient in rats. PTM reduced the formation of malonic dialdehyde and increased the activity of glucose-6-phosphate dehydrogenase in the lungs. Morphometric studies showed that PTM produce a more marked inhibiting effect on exudation in to the alveoli; besides, the administration of PTM contributed greatly to maintenance of the empty space and "total volume" of the alveoli.
ISSN:0031-2991