Do sodium nitroprusside and L-NAME affect pyrogen fever in rabbits?

Thermoregulatory responses after treatment with nitric oxide (NO) donor, sodium nitroprusside (SNP-3 mg/kg/h), or NO synthase inhibitor, NG-nitro-L-arginine methylester (L-NAME-100 mg/kg) were investigated in febrile rabbits (lipopolysaccharide E. coli-1 meg/kg). Pretreatment with SNP attenuated pyr...

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Bibliographic Details
Published inActa physiologica Hungarica Vol. 84; no. 3; p. 289
Main Authors Gagało, I T, Hać, E E, Korolkiewicz, K Z, Matuszek, M T, Szreder, Z
Format Journal Article
LanguageEnglish
Published Hungary 1996
Subjects
Analgesics, Non-Narcotic - pharmacology
Animals
Body Temperature - drug effects
Enzyme Inhibitors - pharmacology
Female
Fever - chemically induced
Male
NG-Nitroarginine Methyl Ester - pharmacology
Nitroprusside - pharmacology
Pyrogens
Rabbits
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Summary:Thermoregulatory responses after treatment with nitric oxide (NO) donor, sodium nitroprusside (SNP-3 mg/kg/h), or NO synthase inhibitor, NG-nitro-L-arginine methylester (L-NAME-100 mg/kg) were investigated in febrile rabbits (lipopolysaccharide E. coli-1 meg/kg). Pretreatment with SNP attenuated pyrogen fever as well as metabolic rate. L-NAME also inhibited postpyrogen increases in metabolism; however, this effect did not lead to antipyresis.
ISSN:0231-424X