Changes in the osteoinductive activity of the bone matrix in ontogeny

Correlation between the animal's age, degree of mineralization of its bone tissue and the osteoinductive activity of the bone organic matrix was established in experiments with rats of the same litter at an age of 2, 4, 8, 16 weeks. The osteoinductive activity was estimated by the capacity of m...

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Bibliographic Details
Published inOntogenez Vol. 19; no. 5; p. 468
Main Authors Sumarokov, D D, Shvyrkov, M B, Shamsudinov, A Kh, Gutkin, D V, Afanasenko, N A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1988
Subjects
Aging - physiology
Animals
Bone Matrix - physiology
Bone Transplantation
Calcification, Physiologic
Calcium - metabolism
Decalcification Technique
Male
Osteogenesis
Phosphorus - metabolism
Rats
Time Factors
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Summary:Correlation between the animal's age, degree of mineralization of its bone tissue and the osteoinductive activity of the bone organic matrix was established in experiments with rats of the same litter at an age of 2, 4, 8, 16 weeks. The osteoinductive activity was estimated by the capacity of matrix to induce ectopic osteogenesis using biochemical methods. Bone mineralization increased and the capacity for osteoinduction decreased roughly 1,5-fold with the age of donor animals. It is suggested that the reduction of osteoinductive potencies is based on the decrease in lability of the bond between the protein osteoinducer and the collagen matrix, as shown by unequal sensitivity of bone matrix of rats of different age to the doubling of the shortest possible time of bone demineralization.
ISSN:0475-1450