An experimental study of the tumor affinity of gallium-67-labelled sphingomyelin liposomes

The level of accumulation of sphingomyelin liposomes with 67-Ga-labelled aqueous phase in tumor tissue proved higher than that of the vesicles with labelled lipid phase. Presence of cholesterol in sphingomyelin liposome membranes failed to influence liposome accumulation in tumor tissue. Neutral sph...

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Bibliographic Details
Published inVoprosy onkologij Vol. 38; no. 9; p. 1080
Main Authors Kostenikov, N A, Fadeev, N P, Serzhanina, V A, Koresakova, L N, Rozenberg, O A
Format Journal Article
LanguageRussian
Published Russia (Federation) 1992
Subjects
Animals
Cholesterol - administration & dosage
Cholesterol - pharmacokinetics
Emulsions
Gallium Radioisotopes
Liposomes
Lymphoma, Non-Hodgkin - diagnostic imaging
Lymphoma, Non-Hodgkin - metabolism
Radionuclide Imaging
Rats
Sphingomyelins - administration & dosage
Sphingomyelins - pharmacokinetics
Time Factors
Tissue Distribution
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Summary:The level of accumulation of sphingomyelin liposomes with 67-Ga-labelled aqueous phase in tumor tissue proved higher than that of the vesicles with labelled lipid phase. Presence of cholesterol in sphingomyelin liposome membranes failed to influence liposome accumulation in tumor tissue. Neutral sphingomyelin vesicles with 67-Ga-labelled aqueous phase offer promise in scintigraphic imaging of tumors.
ISSN:0507-3758