Significance of increase in labelled albumin disappearance rate in arterial hypertension

1. Relationships between labelled albumin disappearance rate (LADR), plasma volume, blood volume, plasma renin activity (PRA) and blood pressure (BP) were studied in normotensive control subjects and patients with hypertension of different aetiology and severity. In essential hypertensive patients w...

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Bibliographic Details
Published inClinical science and molecular medicine. Supplement Vol. 3; p. 211s
Main Authors Ulrych, M, Ulrych, Z
Format Journal Article
LanguageEnglish
Published England 01.12.1976
Subjects
Blood Pressure
Blood Volume
Female
Humans
Hypertension - blood
Male
Renin - blood
Serum Albumin - metabolism
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Summary:1. Relationships between labelled albumin disappearance rate (LADR), plasma volume, blood volume, plasma renin activity (PRA) and blood pressure (BP) were studied in normotensive control subjects and patients with hypertension of different aetiology and severity. In essential hypertensive patients without complications an inverse linear relationship was found between blood pressure and plasma or blood volume. 2. Very close inverse correlations were found between LADR and PRA in both normotensive subjects and patients with uncomplicated essential hypertension. LADR appears to be an excellent reference standard for PRA. 3. It is postulated that LADR mainly reflects the relation between circulating fluid and vascular capacitance tone. LADR is increased in hypertension and blood volume may still be inappropriately high.
ISSN:0144-4107