The phenotypic characteristics and incidence of dyslipoproteinemias in diabetic patients

A total of 121 inpatients with insulin and noninsulin dependent diabetes mellitus were investigated. The patients with noninsulin dependent diabetes mellitus were divided into 2 groups with relation to the presence or absence of secondary resistance to sulfonyl urea derivatives. Changes in the plasm...

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Published inProblemy ėndokrinologii Vol. 36; no. 6; p. 25
Main Authors Kiriakov, A, Koev, D, Kavrykova, Iu, Dimova, Ia, Ovcharova, N, Taneva, T, Tinterova, Z, Borisova, A, Tsoneva, G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1990
Subjects
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Drug Resistance
Humans
Hyperlipoproteinemias - blood
Hyperlipoproteinemias - classification
Hyperlipoproteinemias - epidemiology
Hyperlipoproteinemias - etiology
Incidence
Lipids - blood
Lipoproteins - blood
Phenotype
Sulfanilamides - antagonists & inhibitors
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Summary:A total of 121 inpatients with insulin and noninsulin dependent diabetes mellitus were investigated. The patients with noninsulin dependent diabetes mellitus were divided into 2 groups with relation to the presence or absence of secondary resistance to sulfonyl urea derivatives. Changes in the plasma and lipoprotein concentration of cholesterol (ChS) and triglycerides (TG) were analyzed. According to the author's classification, changes in lipoprotein patterns were distributed in some phenotypes of dyslipoproteinemias (DLP) and their prevalence was studied among the examinees. DLPs were detected in 84.3% of the patients (59.8% were latent). The patients demonstrated a high frequency of hypocholesterolemia of very low density lipoproteins (57.8%) and hypertriglyceridemia of low density lipoproteins (31.4%). These intralipoprotein variations were shown to be the chief element of phenotypical characterization of II (c, d), IV (b, c) and VI (a, b, c) DLP types, not included in Fredrickson's classification.
ISSN:0375-9660