Characteristics of the Na+-K+-cotransport system in the erythrocyte membrane of patients with hypertension and symptomatic (renal) hypertension

The data on erythrocyte membrane permeability for Na and K ions, obtained in the studies of Na+-K+ cotransport in erythrocytes of 38 patients with essential hypertension, stage I and II, 9 patients with borderline hypertension and 12 patients with symptomatic (renal) hypertension are reviewed. The d...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 102; no. 11; p. 542
Main Authors Kavtaradze, V G, Aleksidze, N G, Kvirikadze, N K, Nadiradze, N I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1986
Subjects
Adult
Cell Membrane Permeability
Erythrocyte Membrane - metabolism
Female
Humans
Hypertension - blood
Hypertension, Renal - blood
Ion Channels - metabolism
Male
Middle Aged
Potassium - blood
Sodium - blood
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Summary:The data on erythrocyte membrane permeability for Na and K ions, obtained in the studies of Na+-K+ cotransport in erythrocytes of 38 patients with essential hypertension, stage I and II, 9 patients with borderline hypertension and 12 patients with symptomatic (renal) hypertension are reviewed. The data demonstrate that Na+-K+ cotransport in Na+ loaded and K+-depleted erythrocytes under the effect of P-chlormercuribenzoate was considerably reduced in patients with essential hypertension and borderline hypertension than in the control group. No deviations from the normal Na+-K+ cotransport were observed in renal hypertension. Disturbances of erythrocyte membrane permeability have been also revealed in practically healthy subjects (15 cases) with family history of hypertension.
ISSN:0365-9615