Concentrations of tumor necrosis factor alpha and interleukin-1 beta in cerebrospinal fluid in the course of tick-borne encephalitis

CSF concentrations of TNF-alpha and Il-1 beta were detected in patients with TBE. The cytokines were detected by immunometric assay by MEDGENIX kit. CSF Concentrations of TNF-alpha and IL-1 beta in patients with TBE were significantly higher than in control group before as well as after treatment an...

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Bibliographic Details
Published inPolski merkuriusz lekarski Vol. 4; no. 21; p. 126
Main Authors Kondrusik, M, Hermanowska-Szpakowicz, T, Jaroszewicz, E
Format Journal Article
LanguagePolish
Published Poland 01.03.1998
Subjects
Adolescent
Adult
Encephalitis, Tick-Borne - cerebrospinal fluid
Encephalitis, Tick-Borne - diagnosis
Encephalitis, Tick-Borne - therapy
Female
Humans
Interleukin-1 - cerebrospinal fluid
Male
Middle Aged
Treatment Outcome
Tumor Necrosis Factor-alpha - cerebrospinal fluid
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Summary:CSF concentrations of TNF-alpha and Il-1 beta were detected in patients with TBE. The cytokines were detected by immunometric assay by MEDGENIX kit. CSF Concentrations of TNF-alpha and IL-1 beta in patients with TBE were significantly higher than in control group before as well as after treatment and normalization of CSF parameters. These concentrations were lower comparing to one obtained in group of bacterial meningitis. There was no correlation between concentration of cytokines and other CSF parameters (cytosis, protein, glucose concentration). Concentrations of analysed cytokines did not change significantly before and after treatment. Detection of CSF concentrations of TNF-alpha and Il-1 beta in patients with tick-borne encephalitis can be used to evaluate efficacy of treatment and retreat of infection.
ISSN:1426-9686