Features of metabolic disorders in the liver during morphine poisoning of various duration

Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate w...

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Published inVoprosy meditsinskoi khimii Vol. 38; no. 3; p. 48
Main Authors Gulyĭ, M F, Sinitskiĭ, V N, Stogniĭ, N A, Sushkova, V V, Silonova, N V, Shevtsova, N F, Kas'ianova, N N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1992
Subjects
Animals
Citric Acid Cycle
Energy Metabolism
Glycolysis
Liver - metabolism
Male
Morphine - poisoning
Protein Biosynthesis
Rats
Rats, Wistar
RNA, Transfer, Amino Acyl - metabolism
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Abstract Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.
AbstractList Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.
Author Kas'ianova, N N
Shevtsova, N F
Gulyĭ, M F
Sinitskiĭ, V N
Stogniĭ, N A
Silonova, N V
Sushkova, V V
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Snippet Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of...
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StartPage 48
SubjectTerms Animals
Citric Acid Cycle
Energy Metabolism
Glycolysis
Liver - metabolism
Male
Morphine - poisoning
Protein Biosynthesis
Rats
Rats, Wistar
RNA, Transfer, Amino Acyl - metabolism
Title Features of metabolic disorders in the liver during morphine poisoning of various duration
URI https://www.ncbi.nlm.nih.gov/pubmed/1413651
Volume 38
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