Features of metabolic disorders in the liver during morphine poisoning of various duration

Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate w...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 38; no. 3; p. 48
Main Authors Gulyĭ, M F, Sinitskiĭ, V N, Stogniĭ, N A, Sushkova, V V, Silonova, N V, Shevtsova, N F, Kas'ianova, N N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1992
Subjects
Animals
Citric Acid Cycle
Energy Metabolism
Glycolysis
Liver - metabolism
Male
Morphine - poisoning
Protein Biosynthesis
Rats
Rats, Wistar
RNA, Transfer, Amino Acyl - metabolism
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Summary:Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.
ISSN:0042-8809