Reduction of lipoproteins with apoAI but without apoAII (LpAI) in non-insulin-dependent diabetic patients

• Published in: Annales de biologie clinique (Paris) Vol. 54; no. 2; p. 83
• Main Authors: Barkia, A, Zouari, N, Khrouf, W, Ellouz, F, Zouaghi, H
• Format: Journal Article
• Language: French
• Published: France 1996
• Subjects: Adult; Aged; Apolipoprotein A-I - blood; Apolipoprotein A-I - chemistry; Apolipoprotein A-II - blood; Apolipoproteins B - blood; Diabetes Mellitus, Type 2 - blood; Female; Humans; Lipoproteins, HDL - chemistry; Male; Middle Aged
• ISSN: 0003-3898; 1950-6112

Recent data suggest the existence of a relationship between ischemic heart diseases and apolipoprotein A-I containing lipoproteins. The latter and other classic lipid-lipo-protein-apoprotein parameters were quantified in 25 non-insulin-dependent diabetics and 26 normoglycemic normolipidemic subjects. Compared to a control group, non-insulin-dependent diabetics have higher levels of plasma cholesterol (p < 0.05), triacylglycerol, apolipoprotein B (p < 0.001). In contrast, their lipoprotein particles containing only apolipoprotein AI without apolipoprotein AII and apoAI/apoB ratio were lowered (p < 0.001). In our diabetics, apolipoprotein AI was found at normal level but its distribution between high density lipoproteins ('HDL') and 'non-HDL' was abnormal. Also, the distribution of particles containing apolipoprotein A-I without apolipoprotein A-II in non-insulin-dependent diabetics was found abnormal. A higher proportion of both apoAI and LpAI were found in the 'non-HDL' fraction. These data show that lipoprotein metabolism is affected in non-insulin-dependent diabete mellitus. The disease is associated to a lipoprotein profile which is in favour of the atherogenic process.