Effect of olivomycin on the microsomal oxidation enzymes, the mitochondria and the protein-synthesizing apparatus of the rat liver in acute tetrachloromethane poisoning

Influence of olivomycin an inhibitor of protein biosynthesis on the enzymes of microsomal oxidation, bioenergetic processes in mitochondria and the polyribosomal profile in liver of rats intoxicated with tetrachloromethane was studied. It was established that the pretreatment of rats with olivomycin...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 29; no. 6; p. 54
Main Authors Gubskiĭ, Iu I, Smal'ko, P Ia
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1983
Subjects
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Bilirubin - blood
Carbon Tetrachloride Poisoning - enzymology
Cytochrome P-450 Enzyme System - blood
Endoplasmic Reticulum - drug effects
Endoplasmic Reticulum - enzymology
Male
Microsomes, Liver - drug effects
Microsomes, Liver - enzymology
Mitochondria, Liver - drug effects
Mitochondria, Liver - enzymology
Olivomycins - pharmacology
Rats
Ribosomes - drug effects
Ribosomes - enzymology
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Summary:Influence of olivomycin an inhibitor of protein biosynthesis on the enzymes of microsomal oxidation, bioenergetic processes in mitochondria and the polyribosomal profile in liver of rats intoxicated with tetrachloromethane was studied. It was established that the pretreatment of rats with olivomycin protected the hepatocytes from the effect of tetrachloromethane, reducing the hyperenzymaemia, hyperbilirubinemia, the degree of mitochondrial enzymes inhibition and the destruction of polyribosomes. Administration of olivomycin to healthy animals diminished the cytochrome P-450 content and led to slight changes of polyribosomal profile. Possible mechanisms of the protective effects of olivomycin under conditions of acute hepatic injury are discussed.
ISSN:0042-8809