Changes in the biological properties of influenza virus (HON1) strains virulent for mice when exposed to homologous antibodies

A decrease in the virulent properties of two influenza virus strains (A/PR/8/34 and A/Mel/35 (HON1) pathogenic for mice was demonstrated in multiple passages in chick embryos in the presence of homologous antibody. The artificially developed avirulent A/PR/8/240 and A/Mel/375 variants had low immuno...

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Bibliographic Details
Published inVoprosy virusologiĭ Vol. 29; no. 6; p. 663
Main Authors Smorodintsev, A A, Ivanova, N A, Medvedeva, T E, Grinbaum, E B, Kudriavtseva, V K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1984
Subjects
Animals
Antibodies, Viral - immunology
Antigens, Viral - immunology
Chick Embryo
Cricetinae
Genes, Viral
Immunization
Influenza A virus - genetics
Influenza A virus - immunology
Influenza A virus - pathogenicity
Mice
Mutation
Rabbits
Rats
Temperature
Virulence
Virus Replication
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Summary:A decrease in the virulent properties of two influenza virus strains (A/PR/8/34 and A/Mel/35 (HON1) pathogenic for mice was demonstrated in multiple passages in chick embryos in the presence of homologous antibody. The artificially developed avirulent A/PR/8/240 and A/Mel/375 variants had low immunogenic activity and a marked temperature sensitivity to 40 degrees C. Common ts mutations in the genomes of these avirulent variants located in genes 1 and 7 coding for P3 and M proteins were demonstrated.
ISSN:0507-4088