Experimental evaluation of anti-seborrheic substances

The effects of different drugs on the sebaceous gland is described by the use of an animal model. A castrated rat Wistar was made hyperseborrheic with implant of testosterone. On this model, graduated by a different anti androgen (acetate of cyproterone), anti-seborrheic effect is measured, bound or...

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Bibliographic Details
Published inBulletin de l'Académie nationale de médecine Vol. 178; no. 7; p. 1245
Main Authors Bazex, J, Garigue, J
Format Journal Article
LanguageFrench
Published Netherlands 01.10.1994
Subjects
Animals
Dermatitis, Seborrheic - drug therapy
Disease Models, Animal
Female
Rats
Rats, Wistar
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Summary:The effects of different drugs on the sebaceous gland is described by the use of an animal model. A castrated rat Wistar was made hyperseborrheic with implant of testosterone. On this model, graduated by a different anti androgen (acetate of cyproterone), anti-seborrheic effect is measured, bound or not the antiandrogenic effect of retinoids, cimetidine, spironolactone and, minoxidil. Retinoids reduced the surface of sebaceous glands but did not express an anti-androgenic effect. Cimetidine and spironolactone presented the same action. Minoxidil had no effect on this model.
ISSN:0001-4079