Glucocorticoid kinetics in Cushing's syndrome treated with chloditane and large doses of reserpine

The paper is concerned with the results of the studies on corticosteroid kinetics (secretion rate, distribution volume, metabolic blood clearance, mean daily blood cortisol content and excretion of free hormone with urine) in 44 patients suffering from Icenko-Cushing's disease, treated with chl...

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Bibliographic Details
Published inProblemy ėndokrinologii Vol. 27; no. 3; p. 6
Main Authors Slavnov, V N, Markov, V V, Komissarenko, I V, Cheban, A K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1981
Subjects
Adolescent
Adult
Corticosterone - metabolism
Cushing Syndrome - drug therapy
Cushing Syndrome - metabolism
Drug Therapy, Combination
Humans
Hydrocortisone - metabolism
Kinetics
Middle Aged
Mitotane - administration & dosage
Reserpine - administration & dosage
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Summary:The paper is concerned with the results of the studies on corticosteroid kinetics (secretion rate, distribution volume, metabolic blood clearance, mean daily blood cortisol content and excretion of free hormone with urine) in 44 patients suffering from Icenko-Cushing's disease, treated with chloditane and/or chloditane combined with massive reserpine doses. The above parameters increased in Icenko-Cushing's disease during clinical remission after chloditane or chloditane and reserpine treatment. No differences between effects on glucocorticoid secretion and metabolism after the treatment with chloditane or chloditane in combination with high reserpine doses were recorded.
ISSN:0375-9660