Serotoninergic nerve fibers in the area of the substantia grisea and the ependyma of the cerebral aqueduct

An electron microscopic study of the midbrain gravy with the help of degeneration caused by serotonin-like neurotoxin 5,7-dihydroxytryptamine has shown that serotonergic terminals are responsible for the innervation of dendrites, neuron bodies and ependyma cells of the cerebral aqueduct. The detecti...

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Bibliographic Details
Published inMorfologiia (Saint Petersburg, Russia) Vol. 104; no. 3-4; p. 49
Main Author Semenov, S P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1993
Subjects
5,7-Dihydroxytryptamine - pharmacology
Animals
Cerebral Aqueduct - drug effects
Cerebral Aqueduct - ultrastructure
Desipramine - pharmacology
Ependyma - drug effects
Ependyma - ultrastructure
Male
Microscopy, Electron
Nerve Fibers - drug effects
Nerve Fibers - ultrastructure
Rats
Rats, Wistar
Receptors, Serotonin - drug effects
Receptors, Serotonin - ultrastructure
Time Factors
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Summary:An electron microscopic study of the midbrain gravy with the help of degeneration caused by serotonin-like neurotoxin 5,7-dihydroxytryptamine has shown that serotonergic terminals are responsible for the innervation of dendrites, neuron bodies and ependyma cells of the cerebral aqueduct. The detection of light, dark with prevailing fine transparent or large granular synaptic vesicles as well as vacuole degeneration evidences of the existence of several sources of serotonergic innervation of the central gray substance. Continuous damage of perivascular astrocytes of the central gray by neurotoxin allows a suggestion to be made that they are also the object of serotonergic innervation. Immunomorphological data on the presence of serotoninergic neurons in the cerebral gray are confirmed.
ISSN:1026-3543