Plasma and cellular factors of atherogenesis and the prostanoid system at the early stages of arterial hypertension

In young patients with borderline arterial hypertension and, to a greater extent, with Stage 1 hypertensive disease (HD), changes were found in the proatherogenic plasma lipid and apoprotein composition, which were manifested as higher levels of total cholesterol, triglycerides, low and very low den...

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Bibliographic Details
Published inKardiologiia Vol. 29; no. 9; p. 21
Main Authors Kolomiets, V I, Vasi'lev, Iu M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1989
Subjects
6-Ketoprostaglandin F1 alpha - blood
Adult
Arteriosclerosis - blood
Arteriosclerosis - etiology
Epoprostenol - blood
Female
Humans
Hyperlipidemias - complications
Hypertension - blood
Hypertension - complications
Lipids - blood
Male
Platelet Aggregation - physiology
Thromboxane A2 - blood
Thromboxane B2 - blood
Time Factors
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Summary:In young patients with borderline arterial hypertension and, to a greater extent, with Stage 1 hypertensive disease (HD), changes were found in the proatherogenic plasma lipid and apoprotein composition, which were manifested as higher levels of total cholesterol, triglycerides, low and very low density lipoprotein cholesterols along with increased apolipoprotein B and apolipoprotein B:apolipoprotein AI ratio. The prostacyclin-thromboxane system in borderline arterial hypertension was in an activated state by retaining the physiological ratio of its components. The patients with Stage I HD exhibited a considerable increase in thromboxane activity, which determined the system's imbalance towards its predominance. In Stage I HD, the thrombocytic link of hemostasis was characterized by enhanced platelet aggregability mediated by the imbalance of the prostacyclin-thromboxane system in the direction of thromboxane.
ISSN:0022-9040