Free radical oxidation and tubular dysfunctions in patients with chronic kidney failure

Sixty patients with chronic renal failure (CRF) were studied for the rates of lipid peroxidation (LPO), the state of the antioxidative system (AOS) as well as for the morphofunctional state of biomembranes in renal tubules measured by excretion of low-molecular compounds tested in urine x by means o...

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Published inTerapevtic̆eskii arhiv Vol. 63; no. 6; p. 62
Main Authors Grinshteĭn, Iu I, Lundina, T A, Knubovets, T L, Sibel'dina, L A, Sedov, K R
Format Journal Article
LanguageRussian
Published Russia (Federation) 1991
Subjects
Adolescent
Adult
Antioxidants
Erythrocytes - metabolism
Female
Free Radicals
Humans
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - therapy
Kidney Tubules - physiopathology
Lipid Peroxidation - physiology
Male
Middle Aged
Renal Dialysis
Uremia - physiopathology
Uremia - therapy
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Summary:Sixty patients with chronic renal failure (CRF) were studied for the rates of lipid peroxidation (LPO), the state of the antioxidative system (AOS) as well as for the morphofunctional state of biomembranes in renal tubules measured by excretion of low-molecular compounds tested in urine x by means of proton nuclear magnetic resonance spectroscopy. The control group numbered 35 patients with glomerulonephritis free of functional disturbances in the kidneys. The increased values of malonic dialdehyde levels in red blood cells and blood serum and those of diene conjugates in red blood cell membranes provide evidence for a significant increase of the LPO levels. Furthermore, depression of the AOS was revealed, manifested by the decreased levels of blood serum alpha-tocopherol as well as by unstable levels of superoxide dismutase in red blood cells. In the presence of the high LPO levels significant tubular dysfunctions were progressing, parallel with aggravation of renal function. Disturbances detected in excretion and reabsorption of amino acids (leucine, alanine, glycine, valine, histidine), thin organic acids and ketone bodies in CRF patients point to the existence of disturbances in tubular membranes. Tubular dysfunction appears to be caused by the disturbances of the biomembrane morphofunctional states induced by the high levels of free radical oxidation as well as by the AOS function failure.
ISSN:0040-3660